Cumbria Police said the collision occurred on the A66 near the turn off for Mungrisdale village near Penrith at 13:30 BST on Saturday and involved a red Skoda and an orange Triumph motorcycle.
The rider of the motorcycle, a man in his 20s, died at the scene.
The driver and occupants of the car sustained minor injuries, police said. The road was closed for several hours.
The crash occurred on the A66 near the turn-off for Mungrisdale next to Lisco Farm and involved a red Skoda and an orange Triumph motorcycle.
A police spokesperson said: “The rider of the motorcycle, a man in his 20s, died at the scene of the collision.
“The driver and occupants of the car sustained minor injuries.
“The road was reopened at around 9pm yesterday evening.
